The majority of disease resistance genes in plants encode nucleotide-binding site leucine-rich repeat (NBS-LRR) proteins. This large family is encoded by hundreds of diverse genes per genome and can be subdivided into the functionally distinct TIR-domain-containing (TNL) and CC-domain-containing (CNL) subfamilies. Their precise role in recognition is unknown; however, they are thought to monitor the status of plant proteins that are targeted by pathogen effectors.
An alignment of 65 amino acids from 1,600 NBS sequences used to generate the neighbor-joining trees shown in the following figures.
Neighbor-joining tree showing the family-specific amplification of NBS sequences. (a) TNLs. (b) CNLs. The complete tree was based on 1,600 sequences. Clades that contained sequences from individual plant families were collapsed into single branches and the number of sequences in each branch is indicated. Different taxa are assigned different colors; clades with representatives from several families are shown in black. The scale bar represents five nucleotide substitutions.
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Last modified, May 2007